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Plasmodium falciparum-specific human T cell clones: evidence for helper and cytotoxic activities

✍ Scribed by Francesco Sinigaglia; Hugues Matile; J. Richard; L. Pink

Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 657 KB
Volume: 17
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.1830170206

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✦ Synopsis

This report describes the isolation, and the phenotypic and functional characterization of Plasmodium fulciparum-specific human T lymphocyte clones (TLC) obtained from 2 acutely infected and 4 clinically immune donors. Approximately one third of the TLC obtained from the acutely infected patients had the phenotype CD8+/CD4-. No such clones were obtained from the clinically immune donors. P. fulciparumspecific, major histocompatibility complex-restricted CDS' clones can lyse unrelated tumor cell targets in the presence of anti-CD3 antibodies, suggesting that these clones have cytotoxic potential. Conversely no killing was obtained with two CD4' P. fulciparum-specific TLC, even in the presence of anti-CD3 antibody. In addition the helper function of a CD4' clone was demonstrated in a T/B cell cooperation system.

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