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Plasmodium falciparum ARFGAP: expression and crystallization of the catalytic domain

✍ Scribed by Olga Senkovich; Debasish Chattopadhyay

Book ID
104003256
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
177 KB
Volume
1698
Category
Article
ISSN
1570-9639

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✦ Synopsis

GTPase activating protein for ARF GTPAse (ARFGAP) from the malaria parasite Plasmodium falciparum was expressed, purified and crystallized. Crystals of ARFGAP belong to trigonal space group P321 (or its enantiomorph) with unit cell parameters a = b = 95.89 and c = 92.46 A ˚. Diffraction data to 2.4-A ˚resolution have been collected. Calculation of self-rotation function suggested the presence of two molecules in the asymmetric unit.

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## Abstract Hsp90 is an important cellular chaperone and attractive target for therapeutics against both cancer and infectious organisms. The Hsp90 protein from the parasite __Plasmodium falciparum__, the causative agent of malaria, is critical for this organism's survival; the anti‐Hsp90 drug geld