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Plasminogen (PLG): A useful genetic marker for paternity examinations

✍ Scribed by Weidinger, S. ;Schwarzfischer, F. ;M�ller, H. ;Cleve, H.

Book ID
104662599
Publisher
Springer-Verlag
Year
1985
Tongue
English
Weight
490 KB
Volume
94
Category
Article
ISSN
1437-1596

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✦ Synopsis

The genetically determined polymorphism of plasminogen (PLG) was analyzed by isoelectric focusing on polyacrylamide gels. For analysis neuraminidase-pretreated sera were used. PLG was developed functionally by activation with urokinase and subsequent lysis of casein in an agar overlay. In a random sample of 957 unrelated healthy individuals from Southern Germany, three common phenotypes, PLG1, 2-1, and 2, and five rare variants were found. The allele frequencies were: PLG,1 = 0.7174, PLG,2 = 0.2780, and PLG,Var = 0.0046. The theoretical exclusion rate in cases of disputed paternity is 16.5%.

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