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Plasminogen activators and their inhibitors in leukemic cell homogenates

✍ Scribed by Hideo Wada; Yasurou Kumeda; Zin Ogasawara; Michiaki Ohiwa; Toshihiro Kaneko; Shigehisa Tamaki; Toshiyuki Ohno; Sinichi Kageyama; Thoru Kobayashi; Katsumi Deguchi; Shigeru Shirakawa

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 359 KB
Volume: 42
Category: Article
ISSN: 0361-8609
DOI: 10.1002/ajh.2830420205

No coin nor oath required. For personal study only.

✦ Synopsis

Plasminogen activator (PA) and PA inhibitor (PAI) were measured in homogenates of leukemia cells. Both PA and PA1 levels were higher in non-lymphobiastic leukemia than in lymphobiastic leukemia. The levels were below the sensitivity of determination in chronic myeiocytic leukemia (CML) but showed significant increases in blast crisis (CML,bc). The level of the tissue type PA (t-PA) antigen was highest in acute myelobiastic leukemia (AML) and that of the urokinase type PA (u-PA) was highest in acute promyeiocytic leukemia (APL). The PAM antigen showed no marked cell specificity, but the PAI-ii antigen was markedly increased in myelomonocytic leukemia and acute monocytic leukemia (AMoL). From these findings, various PAS and PAis are considered to be present in leukemia cells and to be involved in hemostatic disorders, thus they are of diagnostic value in leukemia.

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