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Plasmin generation induces neutrophil aggregation: Dependence on the catalytic and lysine binding sites

โœ Scribed by Thomas J. Ryan; Linda Lai; Asrar B. Malik


Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
575 KB
Volume
151
Category
Article
ISSN
0021-9541

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โœฆ Synopsis


We established that plasmin (10-'"M to 10-"M) caused neutrophils (PMN) to aggregate using an in vitro assay Plasminogen had no PMN aggregatory activity even at a concentration of L pM However, plasminogen caused PMN to aggre-


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Thrombin-induced thromboxane generation
โœ R. Bizios; L. Lai; J. W. Fenton II; A. B. Malik ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 462 KB

We examined the effects of thrombin on thromboxane generation by sheep neutrophils and lymphocytes in vitro. Physiological concentration of thrombin (50 nM) resulted in thromboxane B2 generation from both neutrophils and lymphocytes, which was comparable to that obtained with zymosan activated serum