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Plasmin cleavage of vitronectin Identification of the site and consequent attenuation in binding plasminogen activator inhibitor-1

✍ Scribed by Daniel Chain; Tamar Kreizman; Hadar Shapira; Shmuel Shaltiel

Book ID
115925078
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
732 KB
Volume
285
Category
Article
ISSN
0014-5793

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Plasminogen activator inhibitor type-1 (PAI-1) is bound to vitronectin (VN) in plasma and in the extracellular matrix. We previously employed a domainswapping approach to show that the high-affinity binding site for PAI-1 in VN is contained within residues 12-30 in the amino-terminal somatomedin B (