Plasmid patterns and antimicrobial susceptibilities of Neisseria gonorrhoeae in Bandung, Indonesia

✍ Scribed by Tony Djajakusumah; Sunarjati Sudigdoadi; André Meheus; Eddy Van Dyck

• Book ID: 104164884
• Publisher: Elsevier Science
• Year: 1998
• Tongue: English
• Weight: 441 KB
• Volume: 92
• Category: Article
• ISSN: 0035-9203
• DOI: 10.1016/s0035-9203(98)90975-0

✦ Synopsis

Antimicrobial susceptibilities ofNeisseria gonorrhoeae isolates from female sex workers and from men with urethritis in Bandung, Indonesia, were determined by an agar dilution technique. Typing of the Tet M plasmid in tetracycline-resistant isolates (TRNG) was performed using a polymerase chain reaction (PCR) technique and plasmid profiles of penicillinase-producing isolates (PPNG) were determined. All PPNG possessed the 4.4 MDa p-lactamase plasmid and all TRNG showed a PCR fragment characteristic of the 'Dutch' type Tet M plasmid. Of the 50 gonococci isolates tested, all were resistant to tetracycline; 47 wereTRNG, 26 were PPNG, and 6 were resistant to thiamphenicol. Chromosomal resistance to penicillin was not detected. All isolates were susceptible to ceftriaxone, ciprofloxacin, norfloxacin, ofloxacin, kanamycin, spectinomycin, and trimethoprim/sulfamethoxazole. Spectinomycin and fluoroquinolones are useful primary drugs for treatment of gonococcal infection in Bandung. Continued surveillance of antimicrobial resistance should be part of gonorrhoea control in Indonesia.