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Plasmid DNA: Quality, economy, and scale

Book ID
101720579
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
51 KB
Volume
108
Category
Article
ISSN
0006-3592

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## Abstract The advances in gene therapy and genetic vaccination based on plasmid DNA result in an increasing demand of pharmaceutical grade plasmids produced under cGMP. A generic process consisting of a cell disintegration step followed by three different chromatography steps has been developed.