Plasmapheresis versus lymphoplasmapheresis in rheumatoid arthritis: Immunologic comparisons and literature review

✍ Scribed by Daniel J. Wallace; Michael A. Medici; Sherri Nichols; Dr. James R. Klinenberg; Miriam Brck; Richard Gatti; Dennis Goidfinger

• Publisher: John Wiley and Sons
• Year: 1984
• Tongue: English
• Weight: 445 KB
• Volume: 2
• Category: Article
• ISSN: 0733-2459
• DOI: 10.1002/jca.2920020207

✦ Synopsis

Eight patients with Functional Class 111. seropositive. erosive rheumatoid arthritis unresponsive to remitlive drugs each underwent nine aphereseh over 3 w e e k . Four had a 40-inllkg plasma exchange and four other\ had a 40-mli kg plasma exchange plus a mean 5.67 X 10' lymphocyte depletion. Both groups appeared to improve clinically. T and B cell counts and OK T4 and OK T8 ratios decreaced in the I~mphopla~maphcrcsis group. Phytohemagfilutiniii stimulation decreased in lymphoplasmapherchis and increased in plasmapheresis patients with significant comparisons (p = 0.02). These findings confirm and extend previous work. Pla\maphercsis and lyrnphoplasinaphcresis appear to have fundamentally difiercnt action\ on Ipphocyte function.