✦ LIBER ✦

Plasma versus bone marrow desipramine: A comparative study

✍ Scribed by Charles L. Winek; Scott E. Westwood; Wagdy W. Wahba

Book ID: 103903487
Publisher: Elsevier Science
Year: 1990
Tongue: English
Weight: 658 KB
Volume: 48
Category: Article
ISSN: 0379-0738
DOI: 10.1016/0379-0738(90)90271-y

No coin nor oath required. For personal study only.

✦ Synopsis

Correlation between plasma and bone marrow tricyclic antidepressants has not been studied before. Two groups of rabbits were given 10 and 20 mg of desipramine/kg body weight, respectively. Desipramine was administered to the animals once daily by mouth for 5 days. On the fifth day the animals were sacrificed and blood and bone marrow samples were collected and analyzed using a high performance liquid chromatographic (HPLC) method. Data showed that a correlation exists between bone marrow and blood desipramine. The bone marrow desipramine concentration increased as its blood levels increased. The average ratio of bone marrow to blood desipramine +/- S.D. (standard deviation) in both dosage groups was 37.2 +/- 4.46 with a range of 30.99-44.82. This investigation is promising and shows that bone marrow could be used as an alternative tissue in the absence of a suitable blood sample.

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