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Plasma total homocysteine levels and the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene: a study in an Italian population with dementia

✍ Scribed by Teodoro Bottiglieri; Lucilla Parnetti; Erland Arning; Tanya Ortiz; Serena Amici; Alessia Lanari; Virgilio Gallai

Book ID: 114096089
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 100 KB
Volume: 122
Category: Article
ISSN: 0047-6374
DOI: 10.1016/s0047-6374(01)00307-4

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The polymorphic mutation C677T in the gene of MTHFR is considered a risk mutation for spina bifida and vascular disease. Another common mutation on the MTHFR gene, A1298C, has also been described as another risk mutation. We studied the frequencies of these two mutations on DNA samples from healthy