Plasma protein binding of sulphadiazine, sulphamethoxazole and trimethoprim determined by ultrafiltration
✍ Scribed by Agneta Wijkström; Douglas Westerlund
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- English
- Weight
- 515 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0731-7085
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The plasma protein binding of drugs has been shown to have significant effects on the quantitative relationship between clinical pharmacokinetics and pharmacodynamics. In many clinical situations, measurement of the total drug concentration does not provide the needed information concerning the unbo
## Abstract A capillary electrophoretic method for the simultaneous determination of sulfamethoxazole and trimethoprim in plasma was developed. Sulfamethoxazole and trimethoprim extracted from human plasma with ethyl acetate were analyzed at 20 kV and 25°C using 15 mm phosphate buffer (pH 6.2) as t