Plasma protein adsorption and platelet adhesion onto comb-like PEO gradient surfaces

✍ Scribed by Lee, Jin Ho ;Jeong, Bong Jin ;Lee, Hai Bang

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 628 KB
• Volume: 34
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/(sici)1097-4636(199701)34:1<105::aid-jbm14>3.0.co;2-j

✦ Synopsis

Comb-like polyethylene oxide (PEO) surfaces were prepared and electron spectroscopy for chemical analysis. All these on low-density polyethylene (PE). The comb-like PEO chain measurements indicated that the PEO chains are grafted on density was changed gradually along the sample lengths by the PE surface with gradually increasing density of PEO. corona discharge treatment with gradually increasing power Plasma protein adsorption and platelet adhesion on the PEO and the following graft copolymerization of poly(ethylene gradient surfaces decreased with increasing PEO chain glycol) monomethacrylate macromers (PEO-MA). The mac-length and surface density. As observed by scanning electron romers with different PEO repeat unit, 1, 5, and 10, were microscopy, PEO10-MA-grafted surface with high PEO denused. The prepared comb-like PEO gradient surfaces were sity was very effective in preventing protein adsorption and characterized by water contact angle, Fourier transform infra-platelet adhesion and did not activate the platelets. ᭧ 1997 red spectroscopy in the attenuated total reflectance mode, John Wiley & Sons, Inc.