1954U89, 1, 3-diamino-7-(1-ethylpropyl)-8-methyl-7H-pyrrolo-(3, 2-f )quinazoline, is a potent, lipid-soluble inhibitor of dihydrofolate reductase. The pharmacokinetics and bioavailability of 1954U89 were examined in male beagle dogs and male CD rats. Dogs received single intravenous (2Β΄5 mg kg 71 )
β¦ LIBER β¦
Plasma pharmacokinetics and bioavailability of 1-(2-chloroethyl)-3-sarcosinamide-1-nitrosourea after intravenous and oral administration to mice and dogs
β Scribed by Jeffrey G. Supko; Rocio Garcia-Carbonero; Thomas A. Puchalski; Louis Malspeis
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 126 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0344-5704
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