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Plasma nicotine and cotinine in tobacco smoke exposed beagle dogs

โœ Scribed by R.S. Brazell; A.C. Stiff; G.M. Henderson; R.A. Jenkins; P.L. Romig; O. Auerbach

Book ID
113206247
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
652 KB
Volume
73
Category
Article
ISSN
0041-008X

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Disposition kinetics of nicotine and cot
Disposition kinetics of nicotine and cotinine enantiomers in rabbits and beagle dogs
โœ Peyton Jacob III; Neal L. Benowitz; James R. Copeland; Marcus E. Risner; Edward ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 573 KB

The disposition kinetics of nicotine and cotinine enantiomers was determined in rabbits. The clearance of (R)-nicotine was similar to that of (S)-nicotine, but clearance of (R)-cotinine was twice that of (S)-cotinine. Fractional conversions of both enantiomers of nicotine to cotinine were approximat