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Plasma membrane phosphoinositide organization by protein electrostatics

✍ Scribed by McLaughlin, Stuart; Murray, Diana


Book ID
109895525
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
855 KB
Volume
438
Category
Article
ISSN
0028-0836

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A key event in signal transduction in many eukaryotes is activation of polyphosphoinositide‐specific phospholipase C (PIC). This enzyme hydrolyses the plasma membrane‐associated lipid, phosphatidylinositol(4,5)bisphosphate (Ptdlns(4,5)P~2~) which leads to the production of the two second messenger m