Plasma Lipid Peroxidation and Vitamin E Supplementation during High Intakes of Fish-Oil Fatty Acids
✍ Scribed by Wahle, Klaus W. J. ;Brown, Jonathan E.
- Publisher
- John Wiley and Sons
- Year
- 1990
- Weight
- 499 KB
- Volume
- 92
- Category
- Article
- ISSN
- 0931-5985
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✦ Synopsis
High intakes of fish oil concentrates (15gIday MaxEPA) resulted in increased TBARS in plasma after 2 weeks irrespective of the vitamin E intake and plasma content. After 4 weeks TBARS values returned to normal despite continued MaxEPA supplementation and different vitamin E levels. Fish oil supplements resulted in increased whole-blood aggregation and higher plasma glucose concentrations which did not occur when extra vitamin E was given. No significant differences in plasma cholesterol levels were observed.
I n t r o d u c t i o n
1.1. Fish oils and cardiovascular disease
Epidemiological investigations and experimental studies suggest that ingestion of fish or fish lipids has a beneficial effect on cardiovascular function and on the incidence of cardiovascular disease (CVD) in man. The extremely low incidence of CVD in Eskimos is attributed to their high consumption of fish lipids, primarily eicosapentaenoic (20 : 5n-3) (EPA) and docosahexaenoic (22 : 6n-3) (DHA) fatty acids, and occurs despite high overall intakes of fat and cholesterol'. Low incidences of CVD are also found in Japanese fishing communities and are again attributed to their high fish consumption2. The observations that fish oil