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Plasma Levels of Tamoxifen,N-Desmethyl Tamoxifen and Anastrozole in a Patient with Metastatic Breast Cancer and Chronic Hemodialysis

✍ Scribed by T. Langenegger; P. Wahl; D. Schiesser; B. Thürlimann

Book ID: 106377140
Publisher: Springer US
Year: 2006
Tongue: English
Weight: 132 KB
Volume: 100
Category: Article
ISSN: 0167-6806
DOI: 10.1007/s10549-006-9243-7

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## Abstract The relative ability of the antiestrogen, tamoxifen, and its monohydroxy and desmethyl metabolites to displace tritiated estradiol from estrogen receptors isolated from human breast carcinoma was determined. 4‐Hydroxytamoxifen binds to the estrogen receptor with affinity equal to estrad