Plasma levels of 7-hydroxymethotrexate after high-dose methotrexate treatment
β Scribed by G. Milano; A. Thyss; N. Renee; M. Schneider; M. Namer; J. L. Boublil; C. M. Lalanne
- Publisher
- Springer
- Year
- 1983
- Tongue
- English
- Weight
- 281 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0344-5704
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## Abstract A new highβperformance liquid chromatographic assay was used to determine methotrexate (MTX) and its main metabolite, 7βhydroxymethotrexate (7βOHβMTX), in the plasma (n β 17) and urine (n = 14) of children (age 3β12 years) on maintenance therapy for acute lymphocytic leukemia (n = 14) o
A pharmacokinetic study was performed in plasma and cerebrospinal fluid (CSF) of patients suffering from brain tumors to describe the disposition of methotrexate. An open three-compartment model was developed to fit together the data obtained in plasma and CSF. The pharmacokinetic parameters obtaine