Plasma Levels and Distribution of Flavonoids in Rat Brain after Single and Repeated Doses of Standardized Ginkgo biloba Extract EGb 761®
✍ Scribed by Rangel-Ordóñez, Laura; Nöldner, Michael; Schubert-Zsilavecz, Manfred; Wurglics, Mario
- Book ID
- 126088035
- Publisher
- Thieme Medical Publishers
- Year
- 2010
- Tongue
- German
- Weight
- 300 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0032-0943
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The metabolic action of an extract of Ginkgo biloba (EGb 761) has been examined in an ex vivo study of rat erythrocytes. Oral administration of EGb 761 (100 mg/kg/day) for 5 days to Wistar rats caused an increase in the in vitro uptake of glucose by erythrocytes, especially in high-glucose (13.32 mM
The effects of repeated (15-day) oral treatments with an extract of Ginkgo biloba (EGb 761; 50 mg/kg/day) or with its terpenoid constituent, bilobalide (2 mg/kg/day), were assessed in normal rats and in rats that had been previously injected with streptozotocin (50 mg/kg, i.p. in saline solution), a