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Plasma level of chlormethiazole and two metabolites after oral administration to young and aged human subjects

✍ Scribed by R. L. Nation; J. Vine; E. J. Triggs; B. Learoyd


Publisher
Springer
Year
1977
Tongue
English
Weight
943 KB
Volume
12
Category
Article
ISSN
0031-6970

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The plasma levels of chlormethiazole and
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Plasma levels of chlormethiazole and two of its metabolites have been estimated in elderly subjects both after single and repeated oral dosage and on withdrawal. A sensitive analytical method was developed to permit the quantitation of chlormethiazole and its two major metabolites in plasma. The two

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## Abstract After single oral doses of 20 mg of a suspension of dihydralazine sulphate to human subjects, the peak of mean plasma concentrations of dihydralazine of 47Β·0 ng ml^βˆ’1^ Β± 11Β·0 standard deviation (S.D.) (__n__ = 7) was reached at 1 h. Mean concentrations declined biphasically with apparen