Plasma levels of chlormethiazole and two of its metabolites have been estimated in elderly subjects both after single and repeated oral dosage and on withdrawal. A sensitive analytical method was developed to permit the quantitation of chlormethiazole and its two major metabolites in plasma. The two
β¦ LIBER β¦
Plasma level of chlormethiazole and two metabolites after oral administration to young and aged human subjects
β Scribed by R. L. Nation; J. Vine; E. J. Triggs; B. Learoyd
- Publisher
- Springer
- Year
- 1977
- Tongue
- English
- Weight
- 943 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0031-6970
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## Abstract After single oral doses of 20 mg of a suspension of dihydralazine sulphate to human subjects, the peak of mean plasma concentrations of dihydralazine of 47Β·0 ng ml^β1^ Β± 11Β·0 standard deviation (S.D.) (__n__ = 7) was reached at 1 h. Mean concentrations declined biphasically with apparen