Plasma D-dimer and peritoneal CA-125 levels as predictors of disease status in ovarian carcinoma

✍ Scribed by Peter G. Rose; Jill M. Terrien; Stephen Baker

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 429 KB
• Volume: 56
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/jso.2930560309

✦ Synopsis

Abstract

Although serum CA‐125 has improved our ability to monitor tumor response in ovarian carcinoma, ∼50% of patients with normalization of CA‐125 have persistent disease at second look laparotomy. Peritoneal CA‐125 and plasma D‐Dimer levels were studied to determine if their use could increase the sensitivity for persistent ovarian carcinoma in a population of patients with normal physical examinations, radiologic studies, and serum CA‐125 values. Plasma D‐Dimer levels were obtained prior to second look laparotomy. The results of peritoneal CA‐125 and plasma D‐Dimer studies were compared to second look laparotomy results. Differences were evaluated with a one‐way analysis of variance. Twenty‐seven patients were studied. Peritoneal CA‐125 was evaluated in 23 patients and ranged from <6.3–223 U/ml. There was no statistical difference in peritoneal CA‐125 levels between patients whose second look laparotomies were negative, or microscopically or macroscopically positive. D‐Dimer was elevated in three patients, all of whom had macroscopically positive second look findings. The sensitivity for positive second look findings was only 27%. Minimally elevated plasma D‐Dimer levels were specific but not sensitive for persistent disease and peritoneal CA‐125 was not predictive of disease status. © 1994 Wiley‐Liss, Inc.