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Plasma concentrations of endothelin-1 in spontaneously hypertensive rats and DOCA-salt hypertensive rats

✍ Scribed by Nobuhiro Suzuki; Takashi Miyauchi; Yoko Tomobe; Hirokazu Matsumoto; Katsutoshi Goto; Tomoh Masaki; Masahiko Fujino

Book ID: 115762803
Publisher: Elsevier Science
Year: 1990
Tongue: English
Weight: 520 KB
Volume: 167
Category: Article
ISSN: 0006-291X
DOI: 10.1016/0006-291x(90)90614-s

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## Abstract The pharmacokinetics and pharmacodynamics of bumetanide were investigated after intravenous (i.v.) administration, 10 mg kg^−1^, and oral administration, 20 mg kg^−1^, to spontaneously hypertensive rats (SHRs) and deoxycorticosterone acetate‐salt induced hypertensive rats (DOCA‐salt rat