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Plasma concentrations and protein binding of disopyramide and mono-N- dealkyldisopyramide during chronic oral disopyramide therapy.

✍ Scribed by ML Aitio


Book ID
117942509
Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
977 KB
Volume
11
Category
Article
ISSN
0306-5251

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## Abstract Concentrations of disopyramide (D) and mono‐N‐dealkyldisopyramide (MND) were measured in serum and urine following administration of 100, 150, 200, and 300 mg D to four volunteers. The free fraction of D in serum was drug concentration‐dependent in all four subjects following the admini