We have studied the effects of intravenous nicorandil, a mixed arterial and venous vasodilator, in 48 healthy volunteers. Nicorandil (20, 28, 39, 54, 74, 103, 144, or 200 micrograms.kg-1) or placebo were given over 5 min to subjects supine (16 subjects, 2 doses) or sitting (32 subjects, 1 dose) in a
Plasma concentrations and haemodynamic effects of nitroglycerin during and after intravenous infusion in healthy volunteers
✍ Scribed by P. R. Imhof; A. Sieber; J. Hodler; P. Müller; B. Ott; P. Fankhauser; L. -C. Chu; A. Gérardin
- Publisher
- Springer
- Year
- 1982
- Tongue
- English
- Weight
- 741 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0031-6970
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📜 SIMILAR VOLUMES
We have studied the pharmacokinetics and haemodynamic effects of nicorandil after a 12-h infusion. Nicorandil is a mixed vasodilator combining the actions of a nitrate and a potassium channel opener. Nicorandil was infused for 12 h in 21 healthy volunteers at rates of 0.05, 0.10, and 0.20 microgram.
Intravenous, sublingual, or aerosolized nitroglycerin was administered to 19 patients with coronary artery disease during clinically indicated cardiac catheterization. Eight blood samples were collected over 15 min from each patient, and analyzed for content of nitroglycerin, 1 ,Zglycerol dinitrate,