Plasma clearance of 51Cr-EDTA as an estimator of glomerular filtration rate in conscious rats
✍ Scribed by Torben Seefeldt; Donald C. Houghton
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 377 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0260-437X
No coin nor oath required. For personal study only.
✦ Synopsis
A method is described whereby the plasma clearance of "Cr-EDTA is used to estimate the glomerular filtration rate (GFR) in conscious rats. EDTA clearance rates were calculated based on one and two exponential disappearance curves and compared in groups of animals studied under conditions of normal, high and low GFR. Like previously described related methodologies, this technique obviates the need for urine collections and marker infusions for GFR estimates. An important added advantage is that it provides the opportunity to study animals free of the effects of anesthetic, supine position and surgical stress.