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Plasma and cerebrospinal fluid concentrations of temazepam following oral drug administration

โœ Scribed by N. R. Badcock; G. A. Osborne; T. L. M. Nyman; L. N. Sansom; W. J. Russell; D. B. Frewin

Publisher
Springer
Year
1990
Tongue
English
Weight
243 KB
Volume
38
Category
Article
ISSN
0031-6970

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โœฆ Synopsis

Thirteen male patients were administered 20 mg of temazepam orally 1 to 2 h prior to undergoing spinal anaesthesia for a urological procedure. Samples of blood and CSF were drawn just before insertion of the spinal and the concentration of drug estimated in these two media. The results obtained indicated that a highly significant correlation existed between the unbound concentration of temazepam in plasma and the concentration of drug present in CSF. Temazepam appeared to be an effective light pre-medicant in all of the subjects studied.

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