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Plant Derived Antimalarial Agents: New Leads and Challenges

โœ Scribed by Colin W. Wright

Book ID
106496855
Publisher
Springer
Year
2005
Tongue
English
Weight
216 KB
Volume
4
Category
Article
ISSN
1568-7767

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โœ Joรฃo Lavrado; Kaamil Gani; Pedro A. Nobre; Sofia A. Santos; Paula Figueiredo; Di ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 272 KB

Quindolone derivatives, designed to target the malaria parasite digestive vacuole and heme detoxification pathway, have been synthesized by reaction with 2-chloro-N,N-diethylethanamine. This reaction gave N,O-, N,N- and O-alkylated products containing one or two basic side-chains. The compounds were