Planning and Analyzing Adaptive Group Sequential Survival Trials
โ Scribed by Gernot Wassmer
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 191 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0323-3847
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๐ SIMILAR VOLUMES
Procedures are developed in this paper for sample size calculations for planning a group sequential longitudinal trial with various correlation structures, using a test statistic based on generalized estimating equations (Lee, Kim and Tsiatis) and group sequential boundaries based on type I error sp
Simple formulae have been derived for the accurate computation of sample sizes when the two-sample t-test is used. Required sample sizes may be reduced by taking repeated measures, especially if correlations are about equal. In a trial with two parallel groups, repeated measures may be summarized by