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Plakotenin, a new cytotoxic carboxylic acid from the okinawan marine sponge plakortis Sp.

✍ Scribed by Jun'ichi Kobayashi; Shinji Takeuchi; Masami Ishibashi; Hideyuki Shigemori; Takuma Sasaki

Publisher
Elsevier Science
Year
1992
Tongue
French
Weight
183 KB
Volume
33
Category
Article
ISSN
0040-4039

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✦ Synopsis

Plakotenin. a new carboxylic acid with cytotoxic acrivity was isolated from the Okinawan marine sponge PIak$s sp. and the struc~vc elucidated on the basis of spectroscopic data. Marine sponges of the genus Plakortis have been a rich source of a variety of unique bioactive compounds such as polycyclic aromatic alkaloids* or peroxy aliphatic acids and esters.2 We have also isolated a cyclic peroxide, plakorin, as a potent Ca 2+-ATPase activator from an Okinawan Plakortis sponge.3 During our studies on bioactive substances from Okinawan marine organisms.4 we investigated extracts of another

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