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Plakinamines C and D and Three Other New Steroidal Alkaloids from the Sponge Corticium sp.

✍ Scribed by Simona De Marino; Maria Iorizzi; Franco Zollo; Christos Roussakis; Cécile Debitus

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
217 KB
Volume
1999
Category
Article
ISSN
1434-193X

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✦ Synopsis

Five new steroidal alkaloids, plakinamines C (1) and D (2), human bronchopulmonary non-small-cell lung carcinoma cells (NSCLC-N6) with IC 50 values of Ͻ 3.3-5.7 µg/mL. When and the related compounds 3-5 have been isolated from the Vanuatu sponge Corticium sp. Their structures have been tested against T leukemia virus type one (HTLV-I), compounds 1, 4 and 5 were found to exhibit slight anti-HIV elucidated by a detailed spectroscopic analysis, including 2D-HMBC and ROESY correlation experiments. The new activity. compounds show significant in vitro cytotoxicity against respectively. These fractions were chromatographed and the

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