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Placental-like alkaline phosphatase in seminoma

✍ Scribed by Koshida, K. ;Wahren, B.

Book ID
104713783
Publisher
Springer
Year
1990
Tongue
English
Weight
699 KB
Volume
18
Category
Article
ISSN
0300-5623

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✦ Synopsis

Tumor marker identification in testicular cancer has contributed to early detection and monitoring of non-seminomatous disease. A placental alkaline phosphatase-like (PLAP-like) enzyme derived from seminomas has recently been focused upon as a possible marker for this disease. The biochemistry of the PLAP-like enzyme is reviewed, as well as its occurrence in tissue and sera from healthy persons and patients with testicular cancer.

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## Abstract Very high levels of placental‐like alkaline phosphatases (PLAP‐like enzymes) were observed in tissues from 13 typical seminomas. Four tumors with seminoma components contained these enzymes to varying degrees, and other testicular tumors had them in smaller or non‐detectable amounts. An