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Placebo-Controlled Comparison of a Morphine/Dextromethorphan Combination With Morphine on Experimental Pain and Hyperalgesia in Healthy Volunteers

✍ Scribed by Adam R. Frymoyer; Michael C. Rowbotham; Karin Lottrup Petersen


Book ID
119307330
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
220 KB
Volume
8
Category
Article
ISSN
1528-8447

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## Background: Postoperative pain is mediated centrally by n-methyl-d-aspartate (nmda) receptors. the beneficial effects of preincision oral dextromethorphan (dm), which is an nmda antagonist, on postoperative pain and intravenous patient-controlled analgesia (iv-pca) morphine (mo) consumption have