PKU locus: Genetic linkage with human amylase (Amy) loci and assignment to linkage group I

✍ Scribed by J. Kamarýt; A. Mrskoš; Olga Podhradská; Věra Kolcová; Barbara Cabalska; Nina Duczyńska; Jadwiga Borzymowska

• Book ID: 104708625
• Publisher: Springer
• Year: 1978
• Tongue: English
• Weight: 281 KB
• Volume: 43
• Category: Article
• ISSN: 0340-6717
• DOI: 10.1007/bf00293596

✦ Synopsis

The linked alpha-amylase loci Amy 1 and Amy 2 were evaluated for their linkage relationship to the PKU locus using data collected from two (one Czech and one Polish) groups of families. The five sibships informative for Amy 1:PKU give a z score of 1.505 at theta = 0.00 and the eight sibships informative for Amy 2:PKU give a z score of 2.709 at theta = 0.00. Due to the tandem position of Amy 1 and Amy 2 loci, these data could be combined, and linkage between Amy and PKU loci established with a z score 4,214 at theta = 0.00. The practical significance of the linkage, especially for identifying PKU allele carriers, is emphasized.