PIXE investigation of in vitro release of chloramphenicol across polyvinyl alcohol/acrylamide hydrogel

✍ Scribed by M.S. Rihawy; A. Alzier; A.W. Allaf

• Book ID: 103864216
• Publisher: Elsevier Science
• Year: 2011
• Tongue: English
• Weight: 548 KB
• Volume: 269
• Category: Article
• ISSN: 0168-583X
• DOI: 10.1016/j.nimb.2011.05.016

✦ Synopsis

Hydrogels based on polyvinyl alcohol and different amounts of acrylamide monomer were prepared by thermal cross-linking in the solid state. The hydrogels were investigated for drug delivery system applications. Chloramphenicol was adopted as a model drug to study its release behavior. Particle induced Xray emission was utilized to study the drug release behavior across the hydrogels and a comparison study with ultraviolet measurements was performed. Fourier Transform Infrared measurements were carried out for molecular characterization. The releasing behavior of the drug exhibits a decrease and a subsequent increase in the release rate, as the acrylamide monomer increases. Characterization of the hydrogels has shown a competitive behavior between crosslinking with AAm acrylamide monomer or oligomerized version, depending on the amount added to prepare the hydrogels.