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Pivotal Role of Mitochondrial Ca2+ in Microcystin-Induced Mitochondrial Permeability Transition in Rat Hepatocytes

โœ Scribed by Wen-Xing Ding; Han-Ming Shen; Choon-Nam Ong

Book ID
115588369
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
339 KB
Volume
285
Category
Article
ISSN
0006-291X

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โœ Aaron M. Byrne; John J. Lemasters; Anna-Liisa Nieminen ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 356 KB

Previously, we showed that the oxidant chemical, tert-butylhydroperoxide (t-BuOOH), induces a mitochondrial permeability transition (MPT) in intact hepatocytes, causing lethal cell injury. Here, we investigated the role of mitochondrial free Ca2+ in t-BuOOH cytotoxicity to 1-day-cultured rat hepatoc