Pituitary carcinoma : A clinicopathologic study of 15 cases

✍ Scribed by Peter J. Pernicone; Bernd W. Scheithauer; Thomas J. Sebo; Kalman T. Kovacs; Eva Horvath; William F. Young Jr.; Ricardo V. Lloyd; Dudley H. Davis; Barton L. Guthrie; William C. Schoene

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 332 KB
• Volume: 79
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/(sici)1097-0142(19970215)79:4<804::aid-cncr18>3.0.co;2-3

✦ Synopsis

Nelson's syndrome), seven had prolactin-producing tumors, and one had a nonfunctioning tumor. No evidence of diabetes insipidus was seen in any case. Four-1 Departments of Laboratory Medicine and Pateen tumors were initially considered macroadenomas. Of the ten cases for whom thology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota.

tumor extent was known, all had invasive tumors. The interval from the initial diagnosis of adenoma to that of carcinoma ranged from 0.3 to 18.0 years (mean, 2 Departments of Endocrinology and Metabo-6.6 years; median, 5.0 years); the longest mean interval (15.3 years) occurred for lism, Mayo Clinic and Mayo Foundation, Rochpatients with Nelson's syndrome. The latency was twice as long for ACTH-produc-ester, Minnesota.

ing tumors as for prolactin (PRL) cell tumors (9.5 vs. 4.7 years). All carcinomas