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Pituitary and gonadal function during the use of norgestrel-estradiol vaginal rings

✍ Scribed by Juhani Toivonen; Pekka Lähteenmäki; Tapani Luukkainen


Book ID
117084402
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
746 KB
Volume
18
Category
Article
ISSN
0010-7824

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An unexpected enhanced release, in vitro, of estradiol (E2) was observed on the preparation of vaginal rings containing E2 and progesterone (P) in a silicone elastomer. The present work deals with exploring the reason(s) behind this enhanced E2 release. The effect of the ring design (i.e., putting P