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Pituitary adenomas immunocytochemical study of 150 tumors with clinicopathologic correlation

✍ Scribed by Kiyoshi Mukai

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
596 KB
Volume
52
Category
Article
ISSN
0008-543X

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✦ Synopsis

Retrospective immunocytochemical study of prolactin, growth hormone, ACTH, TSH and gonadotropins was performed on 150 pituitary adenomas from 142 patients and the results were correlated with clinical manifestations. There were 60 prolactin-positive tumors, 13 growth hormone-positive tumors, nine ACTH-positive tumors and seven gonadotropin-positive tumors. Seven tumors showed positivity for both prolactin and growth hormone, one tumor was positive for prolactin and ACTH and another was positive for prolactin and TSH. Fifty-two tumors were negative for all the hormones. In the hormone secreting tumors, the results of immunocytochemical study correlated very well with clinical manifestations, while most of the hormone-negative tumors were nonfunctioning clinically. This study demonstrates the reliability of the immunocytochemical method in clinicopathologic study of pituitary adenomas.

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Clinicopathologic study of 123 cases of
Clinicopathologic study of 123 cases of prolactin-secreting pituitary adenomas with special reference to multihormone production and clonality of the adenomas
✍ Wenbin Ma; Hidetoshi Ikeda; Takashi Yoshimoto 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 951 KB

## Abstract ## BACKGROUND Prolactinoma is the most invasive type of pituitary adenoma and is generally believed to be well‐differentiated adenoma and to produce only prolactin (PRL). The factors related to the various biologic behaviors occurring in patients of different ages and sexes await clari