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Pituitary abnormalities in Prader–Willi syndrome and early onset morbid obesity

✍ Scribed by Jennifer L. Miller; Anthony P. Goldstone; Jessica A. Couch; Jonathan Shuster; Guojun He; Daniel J. Driscoll; Yijun Liu; Ilona M. Schmalfuss

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 120 KB
Volume: 146A
Category: Article
ISSN: 1552-4825
DOI: 10.1002/ajmg.a.31677

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## Abstract The neuropathologic abnormalities associated with Prader–Willi syndrome (PWS) are largely unknown. PWS is due to the loss of several paternally expressed genes in chromosome 15q11‐q13 region. Several of the imprinted genes in the 15q11‐q13 region are normally expressed in the brain and