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Pitt-Rogers-Danks syndrome and Wolf-Hirschhorn syndrome

✍ Scribed by D, Donnai


Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
221 KB
Volume
66
Category
Article
ISSN
0148-7299

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From Pitt-Rogers-Danks syndrome to Wolf-
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Apparently normal chromosomes without a molecular 4p16.3 deletion were found in a patient with a Wolf-Hirschhorn syndrome (WHS) phenotype. During a 10-year-period of observation he consistently presented with typical facial appearance, moderate to severe mental retardation, normal physical developme

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Wolf-Hirschhorn syndrome (WHS), a multiple congenital malformation syndrome, and Pitt-Rogers-Danks syndrome (PRDS), a rare condition with similar anomalies, were previously thought to be clinically distinct conditions. While WHS has long been associated with deletions near the terminus of 4p, severa

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