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Pitavastatin Enhanced BMP-2 and Osteocalcin Expression by Inhibition of Rho-Associated Kinase in Human Osteoblasts

✍ Scribed by Keizo Ohnaka; Seiko Shimoda; Hajime Nawata; Hiroaki Shimokawa; Kozo Kaibuchi; Yukihide Iwamoto; Ryoichi Takayanagi


Book ID
115588651
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
201 KB
Volume
287
Category
Article
ISSN
0006-291X

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Core binding factor alpha 1 (Cbfa1) is an osteoblast-specific transcription factor essential to develop a mature osteoblast phenotype. However, its exact role in the signaling of various osteotropic-differentiating agents is still unclear. In this study, we assessed the effects of 1,25-(OH)(2)-D3 (D