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Pirfenidone Treatment Decreases Transforming Growth Factor-β1 and Matrix Proteins and Ameliorates Fibrosis in Chronic Cyclosporine Nephrotoxicity

✍ Scribed by Fuad S. Shihab; William M. Bennett; Hong Yi; Takeshi F. Andoh

Book ID
114423402
Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
339 KB
Volume
2
Category
Article
ISSN
1600-6135

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## Abstract Transforming growth factor‐β (TGF‐β) is a diverse cytokine regulating growth, apoptosis, differentiation, adhesion, invasion, and extracellular matrix production. Dysregulation of TGF‐β is associated with fibrotic disorders and epithelial‐mesenchymal transition, and has been linked with