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Pirfenidone inhibits the induction of iNOS stimulated by interleukin-1β at a step of NF-κB DNA binding in hepatocytes

✍ Scribed by Hideki Nakanishi; Masaki Kaibori; Shigeru Teshima; Hideyuki Yoshida; A-Hon Kwon; Yasuo Kamiyama; Mikio Nishizawa; Seiji Ito; Tadayoshi Okumura

Book ID: 116650437
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 233 KB
Volume: 41
Category: Article
ISSN: 0168-8278
DOI: 10.1016/j.jhep.2004.07.007

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## Abstract ## Objective To examine the role of interferon regulatory factor 1 (IRF‐1) in tumor necrosis factor α (TNFα)–induced interleukin‐18 binding protein a (IL‐18BPa) expression in rheumatoid arthritis synovial fibroblasts (RASFs). ## Methods TNFα‐induced IRF‐1 expression was assessed by r