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Piplartine induces inhibition of leukemia cell proliferation triggering both apoptosis and necrosis pathways

✍ Scribed by Daniel Pereira Bezerra; Gardenia Carmen Gadelha Militão; Fernanda Oliveira de Castro; Cláudia Pessoa; Manoel Odorico de Moraes; Edilberto Rocha Silveira; Mary Anne Sousa Lima; Francisca Juliana Martins Elmiro; Letícia Veras Costa-Lotufo


Book ID
116919497
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
549 KB
Volume
21
Category
Article
ISSN
0887-2333

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Leukemia inhibitory factor (LIF) affects the growth of carcinoma cells, and we thus analyzed its underlying mechanisms. Carcinoma cells constitutively express LIF mRNA, and 23 lines (92.0%) and all (100%) of 25 lines express LIF receptor mRNAs of LIFRb and gp130, respectively. Exogenous addition of