Pioglitazone promotes survival and prevents hepatic regeneration failure after partial hepatectomy in obese and diabetic KK-Ay mice
✍ Scribed by Tomonori Aoyama; Kenichi Ikejima; Kazuyoshi Kon; Kyoko Okumura; Kumiko Arai; Sumio Watanabe
- Book ID
- 102850264
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 699 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0270-9139
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✦ Synopsis
N onalcoholic fatty liver disease (NAFLD) is one of the important manifestations of metabolic syndrome, a clinical entity comprising obesity, hypertension, glucose intolerance, and hyperlipidemia. [1][2][3] NAFLD includes a spectrum of liver pathology ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), which demonstrates progressive diseases, including advanced hepatic fibrosis and hepatocellular carcinoma. [1][2][3] Pathogenesis of metabolic syndrome-related NAFLD/NASH involves a variety of environmental and nutritional factors as well as genetic susceptibilities. Among these, insulin resistance is believed to be the most