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Pioglitazone inhibition of lipopolysaccharide-induced nitric oxide synthase is associated with altered activity of p38 MAP kinase and PI3K/Akt

✍ Scribed by Bin Xing; Tao Xin; Randy Lee Hunter; Guoying Bing

Book ID
119907365
Publisher
BioMed Central
Year
2008
Tongue
English
Weight
1000 KB
Volume
5
Category
Article
ISSN
1742-2094

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## Abstract Excitotoxicity and cell death induced by glutamate are involved in many neurodegenerative disorders. We have previously demonstrated that excitotoxicity induced by millimolar concentrations of glutamate in hippocampal slices involves apoptotic features and glutamate‐induced glutamate re