Pinnatoxins B and C, the most toxic components in the pinnatoxin series from the Okinawan bivalve Pinna muricata

✍ Scribed by Noboru Takada; Naoyoshi Umemura; Kiyotake Suenaga; Tong Chou; Akito Nagatsu; Takeharu Haino; Kaoru Yamada; Daisuke Uemura

• Book ID: 104230548
• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 74 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)00480-4

✦ Synopsis

Pinnatoxins B and C, the most toxic components in the pinnatoxin series, were successfully purified from the Okinawan bivalve Pinna muricata. Their gross structures were determined based on NMR and MS/MS spectral analyses. Their stereostructures were mainly determined by transformation reactions. Pinnatoxins B and C, C-34 epimers of each other, have an amphoteric macrocycle composed of 6,7-spiro, 5,6-bicyclo and 6,5,6-trispiro ketal rings, the same as in pinnatoxins A and D.