✦ LIBER ✦

Pinacidil monohydrate—a novel vasodilator: Review of preclinical pharmacology and mechanism of action

✍ Scribed by Marlene L. Cohen

Publisher: John Wiley and Sons
Year: 1986
Tongue: English
Weight: 639 KB
Volume: 9
Category: Article
ISSN: 0272-4391
DOI: 10.1002/ddr.430090402

No coin nor oath required. For personal study only.

✦ Synopsis

Pinacidil dose-dependently decreased blood pressure in normotensive, renal hypertensive, spontaneously hypertensive, and neurogenic hypertensive rats; in anesthetized cats; and in normotensive and renal hypertensive dogs by a mechanism associated with decreased total peripheral resistance and reflex tachycardia. Pinacidil was 2-4-fold more potent as an antihypertensive than hydralazine. Antihypertensive activity of pinacidil was not modified by a, p, cholinergic, or histaminergic receptor antagonists and was not associated with calcium channel blockade, activation of cyclooxygenase, or formation of the vasodilator, adenosine. In vitro, pinacidil relaxed blood vessels contracted with several agonists

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