## Abstract DNA damage is known to be an initiator of neuronal death in neurodegenerative conditions such as Parkinson's and Alzheimer's diseases. The mechanism linking DNA damage and neuronal death is not completely understood. Here, we delineate the mechanism by which neuronal death evoked by DNA
β¦ LIBER β¦
Pim-1 kinase as activator of the cell cycle pathway in neuronal death induced by DNA damage
β Scribed by Yi Zhang; Mohammad Parsanejad; En Huang; Dianbo Qu; Hossein Aleyasin; Maxime W. C. Rousseaux; Yasmilde Rodriguez Gonzalez; Sean P. Cregan; Ruth S. Slack; David S. Park
- Book ID
- 111183770
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 731 KB
- Volume
- 112
- Category
- Article
- ISSN
- 0022-3042
No coin nor oath required. For personal study only.
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## Abstract Corticosterone (CORT) is well known to induce neuronal damage in various brain regions including the hippocampus, but the precise mechanism(s) of action underlying these effects has yet to be fully established. Insulinβlike growth factorβ1 (IGFβ1) is a trophic factor promoting cell surv